Which one of the following statements about fluoride is false?

The statement regarding the fluoridation of water as an example of topical fluoride application is indeed incorrect. Fluoridation of water is considered a systemic form of fluoride application because it incorporates fluoride into the body and is absorbed through the bloodstream, ultimately benefiting developing teeth. In contrast, topical fluoride application refers to the direct application of fluoride to the surface of teeth, which enhances the resistance of the enamel to decay by providing a localized effect.

The other statements accurately reflect the role of fluoride in dental health. Fluorapatite crystals, formed when fluoride replaces hydroxyl groups in hydroxyapatite, enhance enamel's resistance to acid attacks, making teeth less susceptible to caries. Similarly, fluoride's ability to slow down the metabolic activity of oral bacteria helps in the prevention of tooth decay.